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Immunohistochemical staining. (A) CD3 in neuroendocrine tumors (NET) G1/G2 with stromal T cell infiltration 8/1 high-power fields (HPF); (B) CD3 in NET G3/neuroendocrine carcinomas (NEC) with intratumoral T cell infiltration 10/1 HPF; (C) programmed death-ligand 1 (PD-L1) in NET G1/G2, weak staining in >1% tumor cells; (D) PD-L1 in NET G3/NEC; strong staining >1% of tumor cells original magnification × 300.
