. 2020 Nov 19;9(11):1609. doi: 10.3390/plants9111609

Table 5.

Effect of methanolic extract of Punica granatum leaves (100, 200, 400, and 600 mg/kg; Groups 4–7) on hepatic oxidant–antioxidant parameters in nicotinamide/streptozotocin-induced type 2 diabetes in rats.

Group	Liver
Group	SOD (unit/mg Protein)	CAT (μmol/min/mg Protein)	GPx (μmol/min/mg Protein)	GSH (mM/100 mg Tissue)	MDA (μmol/100 mg Tissue)
Group 1	9.06 ± 1.12	91.8 ± 3.11	11.3 ± 1.09	59.6 ± 2.25	1.07 ± 0.54
Group 2	4.90 ± 0.86 ^a	42.4 ± 2.23 ^a	5.44 ± 0.90 ^a	25.6 ± 1.88 ^a	2.12 ± 0.60 ^a
Group 3	5.89 ± 1.76 ^a	63.1 ± 4.65 ^ab	8.24 ± 2.31 ^ab	44.3 ± 2.50 ^a	1.97 ± 0.32 ^a
Group 4	5.24 ± 0.45 ^a	39.6 ± 2.56 ^a	6.75 ± 1.34 ^a	30.6 ± 2.00 ^a	1.91 ± 0.68 ^a
Group 5	6.50 ± 0.32 ^ab	50.4 ± 3.67 ^a	7.87 ± 1.58 ^a	36.5 ± 2.56 ^a	1.65 ± 0.51 ^a
Group 6	7.27 ± 0.40 ^ab	67.7 ± 3.93 ^ab	8.70 ± 1.55 ^ab	41.3 ± 2.78 ^ab	1.37 ± 0.76 ^ab
Group 7	8.86 ± 0.37 ^b	83.2 ± 3.56 ^b	10.7 ± 1.93 ^b	50.4 ± 2.52 ^b	1.14 ± 0.45 ^b

Data are given as mean ± SEM (n = 6). ^a Significant (p < 0.05) difference compared with the normal group (Group 1). ^b Significant (p < 0.05) difference compared to the diabetic group (Group 2). SOD: superoxide dismutase; CAT: catalase; GPx: glutathione peroxidase; GSH: reduced glutathione; MDA: malondialdehyde.