Table 6.
Effect of methanolic extract of Punica granatum leaves (100, 200, 400, and 600 mg/kg; Groups 4–7) on renal oxidant–antioxidant parameters in nicotinamide/streptozotocin-induced type 2 diabetes in rats.
| Group | Kidney | ||||
|---|---|---|---|---|---|
| SOD (unit/mg Protein) |
CAT (μmol/min/mg Protein) |
GPx (μmol/min/mg Protein) |
GSH (mM/100 mg Tissue) |
MDA (μmol/100 mg Tissue) | |
| Group 1 | 15.2 ± 0.72 | 70.6 ± 3.61 | 12.4 ± 1.98 | 35.3 ± 1.95 | 1.90 ± 0.56 |
| Group 2 | 9.11 ± 0.59 a | 45.4 ± 3.95 a | 6.7 ± 1.08 a | 21.4 ± 1.19 a | 3.03 ± 0.93 a |
| Group 3 | 12.8 ± 0.87 b | 60.5 ± 4.11 b | 10.5 ± 0.92 b | 32.2 ± 1.78 b | 2.80 ± 0.31 a |
| Group 4 | 10.8 ± 0.79 a | 46.5 ± 3.43 a | 8.00 ± 1.09 a | 23.9 ± 1.28 a | 2.94 ± 0.76 a |
| Group 5 | 11.2 ± 0.81 ab | 61.8 ± 3.18 a | 8.05 ± 1.10 a | 27.9 ± 1.56 ab | 2.80 ± 0.83 a |
| Group 6 | 12.8 ± 0.87 b | 66.6 ± 3.72 b | 10.1 ± 1.89 b | 30.9 ± 1.96 b | 2.76 ± 0.48 ab |
| Group 7 | 14.6 ± 0.62 b | 70.5 ± 4.17 b | 12.2 ± 1.65 b | 33.8 ± 1.87 b | 2.01 ± 0.59 b |
Data are given as mean ± SEM (n = 6). a Significant (p < 0.05) difference compared to normal group (Group 1). b Significant (p < 0.05) difference compared to the diabetic group (Group 2). SOD: superoxide dismutase; CAT: catalase; GPx: glutathione peroxidase; GSH: reduced glutathione; MDA: malondialdehyde.