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Overview of sex hormone synthesis and metabolism and the interaction between estrogen and BMPR2 signaling pathways. BMP = bone morphogenetic protein; BMPR2 = bone morphogenetic protein receptor 2; BRE = BMP response element; DHEA = dehydroepiandrosterone; E3 = estriol; ER = estrogen receptor; ERE = estrogen response element; GPER = G-protein-coupled estrogen receptor; hPASMC = human pulmonary artery smooth muscle cell; PH = pulmonary hypertension.
