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. 2020 Nov 27;10:414. doi: 10.1038/s41398-020-01099-4

Fig. 1. Kcnn3 enrichment in anxiety-like and activity-based behaviors and correlations with alcohol drinking in BXD RI strains of mice.

Fig. 1

A Enrichment analysis of K+ channel genes in the BLA and anxiety-related phenotypes. The number contained within each bar represents the number of record IDs for anxiety- and activity-related phenotypes that are significantly correlated with each gene. B, C Significant positive correlations between BLA Kcnn3 expression and open arm entries (GeneNetwork.org Record ID 11714; n = 37 strains) and closed quadrant activity (Record ID 12354; n = 48 strains). D Mapping analysis of the Kcnn3-seeded eigentrait variance generated using the seven phenotypes that have correlations with BLA Kcnn3 expression. Genome-wide significance thresholds are indicated for α = 0.05 (LOD) = 3.67; red dashed line) and α = 0.6 (LOD) = 2.36; gray dashed line) and are based on 1000 permutations of the data. Representative negative correlations between BLA Kcnn3 and alcohol consumption in E a 24-h access model (3% EtOH v/v in 0.2% saccharin; Record ID 10475; n = 9 strains); F the baseline phase of the drinking in the dark (DID) model (20% EtOH v/v; Record ID 20264; n = 31 strains), and G DID drinking following chronic mild stress exposure (Record ID 20288; n = 31 strains). The GeneNetwork probe set for BLA Kcnn3 used for these analyses is Record ID 10493555. r and p values in B, C, and E–G represent Spearman correlation analysis generated in GeneNetwork.