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. 2020 Nov 27;10:414. doi: 10.1038/s41398-020-01099-4

Fig. 2. Drinking and negative affective-like behaviors in mice co-exposed to chronic intermittent alcohol (CIE) and forced swim stress (FSS).

Fig. 2

A Schematic of the two-bottle choice (2BC) drinking model in mice exposed to CIE × FSS. Testing on the marble burying (MB) and novelty-suppressed feeding tests (NSFT) occurred during abstinence in non-drinking mice. 1-EBIO or apamin were administered 30 min prior to home cage drinking or the NSFT. B Alcohol consumption in mice exposed to CIE and daily FSS 4 h prior to home cage alcohol drinking (n = 11–12 mice/group). C The number of marbles buried in a 30-min test period (n = 10–11 mice/group). D, E Latency to consume food on the NSFT and post-test food consumption in the home cage (n = 7–10 mice/group). **p < 0.01 vs all groups in B, D and Air vs CIE mice in FSS groups in C.