Fig. 3. K_Ca2 channels bidirectionally regulate feeding behavior on the novelty-suppressed feeding test in stressed and alcohol dependent mice.

A, B 1-EBIO significantly reduced latency to feed in stressed, dependent mice, without affecting post-test food consumption (n = 7–10 mice/group). C, D Apamin (0.4 mg/kg, i.p.) significantly increased latency to consume food in the NSFT. Food intake in the home cage following the NSFT was reduced by apamin (n = 11–12 mice/group). *p < 0.05, ***p < 0.001 vs vehicle-treated mice. ⁺⁺⁺p < 0.001 vs vehicle and 2.5 mg/kg 1-EBIO in CIE-FSS mice.