Fig. 4. Positive modulation of KCa2 channels reduced alcohol intake.
A Mice escalate voluntary alcohol drinking when given 22 h of access to ethanol (n = 29 mice). 1-EBIO significantly reduced alcohol drinking in the B long- and C short-access home cage (n = 11–12/group) models regardless of treatment group. D, E 1-EBIO did not reduce overall distance traveled or time spent in the center or near the edges of an open field apparatus (n = 18 mice). *p < 0.05, weeks 3, 4, and 5 vs week 1. **p < 0.01, vehicle vs 1-EBIO. ***p < 0.001, edges vs center.