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. 2020 Nov 27;11:6034. doi: 10.1038/s41467-020-19862-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a EEG/EMG traces of a typical cataplexy bout in Hcrt^KO/KO mouse and b the absolute power density for the 40 s EEG signal (10 × 4s epochs) indicated in (a). c Cataplexy number and duration during both baseline and recovery dark periods (one-way ANOVA, genotype F (4, 21) = 11.72 (baseline) and 14.99 (recovery), P < 0.0001, followed by Tukey test). d Wake bout duration (left) and number (right) in the baseline dark period. e Distribution of NREMS bout durations during baseline dark period (one-way ANOVA, genotype F (4, 21) = 9.7 (16 s, P < 0.001), 20.87 (32 s, P < 0.0001) and 18.12 (256 s, P < 0.0001), followed by Tukey test, *P < 0.05; **P < 0.01; ***P < 0.001). Values are mean ± SD. f Time-course of the EEG delta power (1–4 Hz) in all genotypes in the course of the 3-day recording (baselines are averaged). Each dot represents one percentile (see “Methods”) (two-way ANOVA, interaction time × genotype F (124, 651) = 2.58, P < 0.0001, followed by Dunnett’s test, WT vs 5HTT ^{KO /KO} *, 5HTT^+/KO;Hcrt^KO/KO *, DKO *, Hcrt^KO/KO *, P < 0.05, # P < 0.01 WT vs all other genotypes). g EEG power spectra of all genotypes in NREMS during light (left) and dark (right) periods. Insets indicate amplification for specific EEG frequencies and g’ represents the lack of slow-delta activity in cataplexy-exhibiting mice (two-way ANOVA, interaction frequency × genotype F (388, 2037) = 3.244.8 (light), 2.52 (dark), P < 0.0001, followed by Dunnett’s test, WT vs 5HTT^+/KO;Hcrt^KO/KO *, DKO *, 5HTT^KO/KO *, Hcrt^KO/KO * P < 0.05). Values are mean ± SD. h Time-course distribution of TDW amounts. Data points are shown in minutes/hour and represent the average of 2 h (baselines are averaged), (two-way ANOVA, interaction time × genotype F (92, 483) = 2.63, P < 0.0001, followed by Dunnett’s test, WT vs 5HTT^+/KO;Hcrt^KO/KO *, DKO *, 5HTT^KO/KO *, Hcrt^KO/KO * P < 0.05). i EEG power spectra in TDW during light (left) and dark (right) periods. Values are mean ± SD and expressed as the percentage of each mouse’s total baseline EEG power (two-way ANOVA, interaction frequency × genotype F (388, 2037) = 3.37 (light) and 1.84 (dark), P < 0.0001, followed by Dunnett’s test, *P < 0.05; **P < 0.01; ***P < 0.001, WT vs 5HTT^+/KO;Hcrt^KO/KO *, DKO *, 5HTT^KO/KO *, Hcrt^KO/KO *. DKO: n = 7, 5HTT^KO/KO: n = 4, Hcrt^KO/KO: n = 5, 5HTT^+/KO;Hcrt^KO/KO: n = 6 and WT: n = 4.