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. 2020 Nov 27;11:6034. doi: 10.1038/s41467-020-19862-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Distribution in REMS bout durations during the dark period. Lower numbers in each bout duration bin are presented on the x axis. REMS is markedly consolidated in DR_Hcrtr1&2-cKO mice (unpaired 2-tailed t-test, t (8) = 2.27 for 8 s, P = 0.05), 2.88 for 16 s, P < 0.05, and 3.87 for 64 s, P < 0.01, mean ± SEM). b Distribution of NREM bout durations during the dark period. NREMS is highly fragmented in DR_Hcrtr1&2-cKO mice (unpaired two-tailed t-test, t (8) = 3.25 for 8 s, P < 0.05, 2.86 for 16 s, P < 0.05), 2.36 for 32 s, P < 0.05, 3.61 for 64 s, P < 0.01, 2.41 for 128 s, P < 0.05) and 3.39 for 256 s, P < 0.01, mean ± SEM). c Baseline waking EEG power spectra during light (left) and dark (right) periods. Data are normalized to the total EEG power during baseline. Insets show higher magnification of lower frequencies (two-way ANOVA, interaction frequency × genotype F (196, 1568) = 3.86 (light), 5.7 (dark), P < 0.0001, followed by Dunnett’s test, horizontal bars join frequency bins for which P < 0.05). d Baseline EEG power spectra for NREMS (two-way ANOVA, interaction frequency × genotype F (196, 1568) = 2.26 (light), 1.81 (dark), P < 0.0001, followed by Dunnett’s test, P < 0.05). e Baseline EEG power spectra for REMS (two-way ANOVA, interaction frequency × genotype F (196, 1568) = 6.51 (light), 7.15 (dark), P < 0.0001, followed by Dunnett’s test, P < 0.05). f The slow-delta in NREMS of Hcrt^KO/KO and DR_Hcrtr1&2-cKO mice. Hcrt^KO/KO mice show a profound decrease, while the disruption of HCRT input to the DR largely enhances NREMS slow-delta power (two-way ANOVA, interaction frequency × genotype F (388, 2037) = 2.52 (left), F (196, 1568) = 2.26 (right), P < 0.0001, followed by Dunnett’s test, WT vs. Hcrt^KO/KO* and vs. DR_Hcrtr1&2-cKO* P < 0.05). DR_Hcrtr1&2-cKO n = 5, and control mice n = 5.