Table 3.
Significantly different protein peaks in urine samples compared between CKD stage 2, 3, 4, and 5 groups.
| Mw (Da) | Theoretical Mw (Da) | CKD stage 2 group (peak value) | CKD stage 3 group (peak value) | CKD stage 4 group (peak value) | CKD stage 5 group (peak value) | P | Protein name | Protein symbol |
|---|---|---|---|---|---|---|---|---|
| 1178.25 | N/A | 1.16 (0.70–2.37) | 0.23 (− 0.13 to 1.73) | 0.16 (− 0.32 to 1.35) | 1.83 (0.42–3.80)c | 0.013 | N/A | N/A |
| 1251.78 | N/A | 1.56 (1.11–2.46) | 0.49 (− 0.47 to 1.31)a | 0.61 (0.11–1.83) | 1.29 (0.15–3.77) | 0.021 | N/A | N/A |
| 3079.82 | 3079 | 0.08 (− 0.19 to 0.55) | 0.02 (− 0.33 to 0.47) | 0.44 (0.11–1.15)b | 0.55 (0.09–1.09)b | 0.008 | Neuropeptide B | NPB |
| 4017.60 | 4021 | 0.96 (0.39–1.75) | 0.83 (0.29–1.50) | 1.44 (0.65–2.11) | 0.44 (0.07–0.89)c | 0.013 | Vasopressin-neurophysin 2-copeptin | AVP |
| 9536.92 | 9539 | 0.11 (− 0.02 to 0.27) | 0.21 (0.08–0.61) | 0.24 (0.14–0.39) | 0.33 (0.24–0.82)a | 0.010 | High mobility group nucleosome-binding domain-containing protein 4 | HMGN4 |
| 10,782.9 | 10,785 | 0.12 (0.03–0.49) | 0.16 (0.06–0.48) | 0.28 (0.16–0.56) | 0.14 (0.00–0.19)c | 0.035 | Immunoglobulin heavy variable 4–31 or T cell receptor delta variable 2 | IGHV4–31 or TRDV2 |
| 10,853.9 | 10,853 | 0.17 (0.02–0.29) | 0.20 (0.04–0.37) | 0.26 (0.04–0.53) | 0.05 (− 0.01 to 0.14)c | 0.026 | Immunoglobulin heavy variable 3–7 or Uncharacterized protein EXOC3-AS1 | IGHV3–7 or EXOC3-AS1 |
aMeans compared with CKD stage 2 group, P < 0.05.
bMeans compared with CKD stage 3 group, P < 0.05.
cMeans compared with CKD stage 4 group, P < 0.05.