Table 1.

Analysis of enrichment of KEGG pathways and involved genes against tobacco-flavored e-liquids.

Name	Involved genes	p-value
Ribosome	RPL18, RPSA, RPL13, RPL35, RPL27, RPS9, RPS2, RPS5, MRPS2, RPL29, MRPL24, MRPL23, MRPL12, MRPL28, RPL18A, RPL13A, RPLP0, RPL8, RPL10, RPS10, RPL7A	0.000
Glycolysis/Gluconeogenesis	PKM, GPI, LDHA, PFKL, GCK, ALDH1B1, PGM1, ALDH3B2, ALDH3B1, ENO1	0.003
Arginine and proline metabolism	PYCRL, CKMT1A, CKMT1B, SRM, ALDH1B1, GAMT, NOS3, PRODH, CKB	0.006
beta-Alanine metabolism	AOC2, GAD1, AOC3, SRM, ALDH1B1, ALDH3B2, ALDH3B1	0.006
Bladder cancer	CXCL8, HBEGF, CDKN2A, FGFR3, TP53, THBS1, CDK4, MYC	0.007
Phenylalanine metabolism	AOC2,AOC3, ALDH3B2, ALDH3B1, MIF	0.012
Pertussis	FOS, IL6, IL23A, C3, LY96, JUN, CXCL8, PYCARD, CALML5, CD14	0.022
Galactose metabolism	HKDC1, AKR1B10, B4GALT2, PFKL, GCK, PGM1	0.023
Legionellosis	IL6, CXCL3, CXCL2, C3, PYCARD, CXCL8, CD14, HSPA8	0.028
p53 signaling pathway	CCNG2, GADD45A, STEAP3, CDKN2A, TP53, DDB2, SFN, THBS1, CDK4	0.030
Starch and sucrose metabolism	GPI, GCK, PYGL, PGM1, PYGB	0.033
Salmonella infection	FOS, IL6, CXCL3, JUN, CXCL2, CXCL8, WASL, PYCARD, FLNB, CD14	0.039
Alanine, aspartate and glutamate metabolism	GFPT1, ASNS, GAD1, GLUL, ADSL, CAD	0.042
Small cell lung cancer	TRAF1, PTGS2, COL4A2, LAMA5, LAMC3, RXRA, TP53, CDK4, MYC, PIK3R2	0.044
DNA replication	MCM7, LIG1, POLD2, MCM2, MCM3, MCM5	0.046