Table 4.
Go annotation of predicted targets in menthol-flavored e-liquid.
| Term | Count | % | p-value |
|---|---|---|---|
| Molecular function | |||
| GO:0016614 ~ oxidoreductase activity, acting on CH-OH group of donors | 15 | 2.560 | 1.32E-04 |
| GO:0016616 ~ oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 13 | 2.218 | 3.79E-04 |
| GO:0005102 ~ receptor binding | 71 | 12.116 | 4.36E-04 |
| GO:0005509 ~ calcium ion binding | 40 | 6.826 | 9.26E-04 |
| GO:0050662 ~ coenzyme binding | 16 | 2.730 | 9.42E-04 |
| GO:0048037 ~ cofactor binding | 20 | 3.413 | 1.35E-03 |
| GO:0033764 ~ steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 6 | 1.024 | 1.50E-03 |
| GO:0016709 ~ oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | 7 | 1.195 | 2.36E-03 |
| GO:0016229 ~ steroid dehydrogenase activity | 6 | 1.024 | 2.85E-03 |
| GO:0047086 ~ ketosteroid monooxygenase activity | 3 | 0.512 | 3.02E-03 |
| Biological processes | |||
| GO:0010033 ~ response to organic substance | 153 | 26.109 | 9.81E-12 |
| GO:0070887 ~ cellular response to chemical stimulus | 145 | 24.744 | 2.20E-11 |
| GO:0009966 ~ regulation of signal transduction | 144 | 24.573 | 3.80E-10 |
| GO:0010646 ~ regulation of cell communication | 155 | 26.451 | 4.54E-10 |
| GO:0023051 ~ regulation of signaling | 156 | 26.621 | 7.93E-10 |
| GO:0071310 ~ cellular response to organic substance | 118 | 20.137 | 8.13E-09 |
| GO:1901700 ~ response to oxygen-containing compound | 88 | 15.017 | 1.07E-08 |
| GO:0023057 ~ negative regulation of signaling | 73 | 12.457 | 1.00E-07 |
| GO:0010647 ~ positive regulation of cell communication | 88 | 15.017 | 1.55E-07 |
| GO:0009968 ~ negative regulation of signal transduction | 68 | 11.604 | 1.77E-07 |
| Cellular component | |||
| GO:0044421 ~ extracellular region part | 196 | 33.447 | 2.19.E-10 |
| GO:0005576 ~ extracellular region | 214 | 36.519 | 5.55.E-08 |
| GO:1903561 ~ extracellular vesicle | 142 | 24.232 | 4.58.E-07 |
| GO:0043230 ~ extracellular organelle | 142 | 24.232 | 4.63.E-07 |
| GO:0070062 ~ extracellular exosome | 141 | 24.061 | 5.74.E-07 |
| GO:0031988 ~ membrane bounded vesicle | 167 | 28.498 | 5.72.E-06 |
| GO:0005578 ~ proteinaceous extracellular matrix | 28 | 4.778 | 1.11.E-04 |
| GO:0005615 ~ extracellular space | 74 | 12.628 | 3.42.E-04 |
| GO:0005829 ~ cytosol | 148 | 25.256 | 5.52.E-04 |
| GO:0031012 ~ extracellular matrix | 33 | 5.631 | 1.24.E-03 |
The top 10 most enriched GO terms are listed in terms for biological process, cellular component, and molecular function based on p-values.