Table 6.
List of top 20 up and down regulated transcripts in menthol-flavored e-liquids.
| Gene name | HGNC. ID | Full description of the gene | Fold change (log2) | p value |
|---|---|---|---|---|
| Up regulated genes | ||||
| CRYAB | 2389 | Crystallin alpha B | 7.798 | 0.001 |
| MMP1 | 7155 | Matrix metallopeptidase 1 | 7.435 | 0.000 |
| AKR1C1 | 384 | Aldo–keto reductase family 1 member C1 | 7.430 | 0.000 |
| HSPA6 | 5239 | Heat shock protein family A (Hsp70) member 6 | 7.341 | 0.000 |
| IL24 | 11346 | Interleukin 24 | 6.707 | 0.000 |
| HKDC1 | 23302 | Hexokinase domain containing 1 | 6.501 | 0.000 |
| ARC | 648 | Activity regulated cytoskeleton associated protein | 6.477 | 0.000 |
| CYP4F3 | 2646 | Cytochrome P450 family 4 subfamily F member 3 | 6.443 | 0.002 |
| HMOX1 | 5013 | Heme oxygenase 1 | 6.028 | 0.000 |
| LCP1 | 6528 | Lymphocyte cytosolic protein 1 | 5.995 | 0.000 |
| CCL26 | 10625 | C–C motif chemokine ligand 26 | 5.977 | 0.001 |
| IL1RL1 | 5998 | Interleukin 1 receptor like 1 | 5.890 | 0.000 |
| NEFM | 7734 | Neurofilament, medium polypeptide | 5.699 | 0.000 |
| SDCBP2 | 15756 | Syndecan binding protein 2 | 5.233 | 0.000 |
| RASD1 | 15828 | Ras related dexamethasone induced 1 | 5.226 | 0.000 |
| EFR3B | 29155 | EFR3 homolog B | 4.903 | 0.001 |
| CLU | 2095 | Clusterin | 4.697 | 0.000 |
| MAP1B | 6836 | Microtubule associated protein 1B | 4.591 | 0.000 |
| AKR1B10 | 382 | Aldo–keto reductase family 1 member B10 | 4.563 | 0.000 |
| SLC7A11 | 11059 | Solute carrier family 7 member 11 | 4.467 | 0.000 |
| Down regulated genes | ||||
| CA9 | 1383 | Carbonic anhydrase 9 | − 6.849 | 0.001 |
| INPP5D | 6079 | Inositol polyphosphate-5-phosphatase D | − 6.456 | 0.000 |
| PLCB2 | 9055 | Phospholipase C beta 2 | − 4.747 | 0.000 |
| PADI3 | 18337 | Peptidyl arginine deiminase 3 | − 4.680 | 0.001 |
| MXRA5 | 7539 | Matrix remodeling associated 5 | − 4.641 | 0.001 |
| RDH16 | 29674 | Retinol dehydrogenase 16 (all-trans) | − 4.583 | 0.001 |
| ALDH3B2 | 411 | Aldehyde dehydrogenase 3 family member B2 | − 4.395 | 0.002 |
| MX2 | 7533 | MX dynamin like GTPase 2 | − 4.356 | 0.000 |
| HAGHL | 14177 | Hydroxyacylglutathione hydrolase-like | − 4.279 | 0.000 |
| RARRES3 | 9869 | Retinoic acid receptor responder 3 | − 4.273 | 0.000 |
| MAMDC4 | 24083 | MAM domain containing 4 | − 4.257 | 0.000 |
| CAPS | 1487 | Calcyphosine | − 4.245 | 0.000 |
| IFITM1 | 5412 | Interferon induced transmembrane protein 1 | − 4.207 | 0.000 |
| HBQ1 | 4833 | Hemoglobin subunit theta 1 | − 4.162 | 0.000 |
| CDH8 | 1767 | Cadherin 8 | − 4.114 | 0.001 |
| PRODH | 9453 | Proline dehydrogenase 1 | − 4.113 | 0.000 |
| SDK2 | 19308 | Sidekick cell adhesion molecule 2 | − 4.085 | 0.001 |
| MMP28 | 14366 | Matrix metallopeptidase 28 | − 4.084 | 0.000 |
| CYP24A1 | 2602 | Cytochrome P450 family 24 subfamily A member 1 | − 4.082 | 0.000 |
| SOX18 | 11194 | SRY-box 18 | − 4.063 | 0.000 |