Table 2.
SARS-COV-2-specific IgG levels in COVID-19 patients according to age.
| Age (<40 yrs) | Age (40–65 yrs) | Age (>65 yrs) | P value 1* | P value 2# | |
|---|---|---|---|---|---|
| On admission, median (IQR) | |||||
| RBD | 11.6 (3.6–20.0) | 20.4 (9.2–43.9) | 9.8 (5.5–39.9) | 0.2 | 0.5 |
| S | 21.3 (5.5–38.5) | 18.9 (11.3–35.4) | 20.7 (8.1–37.8) | 0.9 | 0.8 |
| N | 8.4 (5.4–14.1) | 15.7 (6.2–25.2) | 20.3 (10.4–28.0) | 0.4 | 0.3 |
| Highest level during hospitalization, median (IQR) | |||||
| RBD | 7.7 (2.5–15.8) | 22.4 (13.4–37.5) | 30.7 (14.0–54.4) | <0.0001 | 0.003 |
| S | 8.9 (4.6–20.4) | 22.9 (12.5–32.3) | 28.0 (17.2–45.1) | <0.0001 | 0.0004 |
| N | 7.2 (4.1–19.7) | 12.1 (6.5–21.3) | 19.4 (9.3––38.1) | 0.04 | <0.0001 |
| On discharge, median (IQR) | |||||
| RBD | 7.1 (5.4–17.6) | 20.4 (11.1–37.1) | 27.4 (12.3–45.2) | 0.006 | 0.1 |
| S | 11.5 (5.9–21.1) | 23.7 (12.5–34.3) | 25.2 (15.8–40.8) | 0.01 | 0.1 |
| N | 8.2 (4.2–17.8) | 10.9 (4.7–27.2) | 16.2 (7.5–28.9) | 0.4 | 0.1 |
*P values of two-sided Wilcoxon rank-sum test between patients aged younger than 40 years and 40–65 years.
#P values of two-sided Wilcoxon rank-sum test between patients aged 40–65 years and older than 65 years.
COVID-19 coronavirus disease 2019, IgG immunoglobulin G, N nucleoprotein, RBD receptor-binding domain, S spike, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2.