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. 2020 Nov 27;3:720. doi: 10.1038/s42003-020-01441-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Mammary fat pad tumor growth in syngeneic mice injected with E0771 (n = 8 or 9 biologically independent mice per group). Data representative of three independent experiments. Arrows indicate dates in which anti-PD-1 treatment was given. b Waterfall plot showing change in E0771 tumor volume compared to baseline prior to treatment. c Individual tumor volume as a function of time. Each line represents a single mouse (n = 17 or 19 biologically independent mice per group). d Representative image of raw flow cytometry data looking at LAG3 and PD-1 expression on tumor-infiltrating CD8⁺ T cells. Percentage of (e) PD-1⁺ LAG3^- and (f) PD-1⁺ LAG3⁺ of CD8⁺ T cells. Mean ± SD. Statistical significance was determined by two-way ANOVA. If statistical significance is not indicated in the figure, p > 0.05.