Table 1.
RNA-seq analysis of in vivo-grown control and shRNA-mediated depletion of DDR2 NA13 tumors, treated with IgG or anti-PD-1.
| Gene | log2 Fold Change-Ctrl PD-1 vs Ctrl IgG | P value | FDR | log2 Fold Change-shDDR2 PD-1 vs Ctrl PD-1 | P value | FDR |
|---|---|---|---|---|---|---|
| Adam10 | −0.822596659 | 0.020806363 | 0.045585636 | 0.406506375 | 0.48972383 | 0.69464212 |
| Anpep | −1.59767458 | 1.97872E-05 | 4.33527E-05 | 2.158521221 | 0.000295296 | 0.000418858 |
| Ccl2 | 1.571613003 | 2.14919E-07 | 4.70876E-07 | −1.288996781 | 0.021993815 | 0.031196828 |
| Cd37 | −0.042166571 | 0.941459914 | 0.9999 | 1.410860957 | 0.058872555 | 0.083506977 |
| Col1a1 | −0.167174285 | 0.704017938 | 0.9999 | 0.80177797 | 0.341239809 | 0.484026975 |
| Cxcl12 | 0.60349953 | 0.094849721 | 0.207810699 | 0.50336306 | 0.379091454 | 0.537717127 |
| Cxcr4 | 0.650687462 | 0.034177217 | 0.074880467 | −0.306546059 | 0.572535787 | 0.812105616 |
| Dpp4 | 1.338848907 | 0.022922195 | 0.050221311 | 0.34210444 | 0.649167245 | 0.920802468 |
| E2f1 | −0.010405546 | 0.967081161 | 0.9999 | 0.158559888 | 0.790202949 | 0.9999 |
| Erbb2 | −0.849235451 | 0.009699223 | 0.021250482 | 0.31783298 | 0.577566925 | 0.819241966 |
| F3 | −0.370653036 | 0.270870723 | 0.593463358 | −0.159093063 | 0.763568714 | 0.9999 |
| Faah | −0.439111486 | 0.557325622 | 0.9999 | 1.216752365 | 0.116775867 | 0.165639143 |
| Fap | 1.630442692 | 4.19435E-05 | 9.1896E-05 | −0.893607113 | 0.122541449 | 0.173817256 |
| Gstp1 | 0.439742236 | 0.199664558 | 0.437454436 | −0.460375803 | 0.369549503 | 0.524182477 |
| Il7r | −0.278499577 | 0.583310576 | 0.9999 | 1.313357477 | 0.035733225 | 0.050685308 |
| Mmp14 | −0.32431483 | 0.323697891 | 0.709204875 | 0.410117128 | 0.48862662 | 0.693085797 |
| Mmp2 | −0.613897569 | 0.076753939 | 0.168163802 | 0.972047317 | 0.079696089 | 0.113043836 |
| Mmp9 | 0.083811224 | 0.812235689 | 0.9999 | −0.21140455 | 0.697798397 | 0.989782665 |
| Pdk1 | 0.114935953 | 0.708139487 | 0.9999 | −0.349615903 | 0.531679849 | 0.754154066 |
| Ptk2b | −0.796466967 | 0.04643294 | 0.101732105 | 0.402383049 | 0.487882786 | 0.692030716 |
| Rps6kb1 | −0.17291805 | 0.556540513 | 0.9999 | −0.150150265 | 0.773998339 | 0.9999 |
| Slc3a2 | −0.262119972 | 0.434579646 | 0.952140908 | 0.320402368 | 0.589868823 | 0.836691427 |
| Vegfc | 0.037866013 | 0.965403498 | 0.9999 | 0.037600307 | 0.964890214 | 0.9999 |
‘Ctrl PD-1 vs Ctrl IgG’ depicts comparisons between scramble shRNA control treated with anti-PD-1 vs. IgG control. ‘shDDR2 PD-1 vs. Ctrl PD-1’ depicts DDR2- targeting shRNA vs scramble shRNA control treated with anti-PD-1.