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. 2020 Nov 27;3:720. doi: 10.1038/s42003-020-01441-y

Table 1.

RNA-seq analysis of in vivo-grown control and shRNA-mediated depletion of DDR2 NA13 tumors, treated with IgG or anti-PD-1.

Gene log2 Fold Change-Ctrl PD-1 vs Ctrl IgG P value FDR log2 Fold Change-shDDR2 PD-1 vs Ctrl PD-1 P value FDR
Adam10 −0.822596659 0.020806363 0.045585636 0.406506375 0.48972383 0.69464212
Anpep −1.59767458 1.97872E-05 4.33527E-05 2.158521221 0.000295296 0.000418858
Ccl2 1.571613003 2.14919E-07 4.70876E-07 −1.288996781 0.021993815 0.031196828
Cd37 −0.042166571 0.941459914 0.9999 1.410860957 0.058872555 0.083506977
Col1a1 −0.167174285 0.704017938 0.9999 0.80177797 0.341239809 0.484026975
Cxcl12 0.60349953 0.094849721 0.207810699 0.50336306 0.379091454 0.537717127
Cxcr4 0.650687462 0.034177217 0.074880467 −0.306546059 0.572535787 0.812105616
Dpp4 1.338848907 0.022922195 0.050221311 0.34210444 0.649167245 0.920802468
E2f1 −0.010405546 0.967081161 0.9999 0.158559888 0.790202949 0.9999
Erbb2 −0.849235451 0.009699223 0.021250482 0.31783298 0.577566925 0.819241966
F3 −0.370653036 0.270870723 0.593463358 −0.159093063 0.763568714 0.9999
Faah −0.439111486 0.557325622 0.9999 1.216752365 0.116775867 0.165639143
Fap 1.630442692 4.19435E-05 9.1896E-05 −0.893607113 0.122541449 0.173817256
Gstp1 0.439742236 0.199664558 0.437454436 −0.460375803 0.369549503 0.524182477
Il7r −0.278499577 0.583310576 0.9999 1.313357477 0.035733225 0.050685308
Mmp14 −0.32431483 0.323697891 0.709204875 0.410117128 0.48862662 0.693085797
Mmp2 −0.613897569 0.076753939 0.168163802 0.972047317 0.079696089 0.113043836
Mmp9 0.083811224 0.812235689 0.9999 −0.21140455 0.697798397 0.989782665
Pdk1 0.114935953 0.708139487 0.9999 −0.349615903 0.531679849 0.754154066
Ptk2b −0.796466967 0.04643294 0.101732105 0.402383049 0.487882786 0.692030716
Rps6kb1 −0.17291805 0.556540513 0.9999 −0.150150265 0.773998339 0.9999
Slc3a2 −0.262119972 0.434579646 0.952140908 0.320402368 0.589868823 0.836691427
Vegfc 0.037866013 0.965403498 0.9999 0.037600307 0.964890214 0.9999

‘Ctrl PD-1 vs Ctrl IgG’ depicts comparisons between scramble shRNA control treated with anti-PD-1 vs. IgG control. ‘shDDR2 PD-1 vs. Ctrl PD-1’ depicts DDR2- targeting shRNA vs scramble shRNA control treated with anti-PD-1.