Table 1.

The gene ontology analysis of genes co-expressed with AQP9 in LinkedOmics database.

Cancer	GO Term	GeneSet	Description	Count	p-value	FDR
BRCA	BP	GO:0002250	Adaptive immune response	368	0	0
		GO:0045088	Regulation of innate immune response	350	0	0
		GO:0036230	Granulocyte activation	476	0	0
		GO:0002446	Neutrophil mediated immunity	473	0	0
		GO:0002694	Regulation of leukocyte activation	461	0	0
		GO:0002764	Immune response-regulating signaling pathway	452	0	0
		GO:0032615	Interleukin-12 production	53	0	0
		GO:0032612	Interleukin-1 production	86	0	0
		GO:0002449	Lymphocyte mediated immunity	229	0	0
		GO:0042110	T cell activation	439	0	0
		GO:0002683	Negative regulation of immune system process	392	0	0
		GO:0050727	Regulation of inflammatory response	349	0	0
		GO:0002697	Regulation of immune effector process	365	0	0
		GO:0032635	Interleukin-6 production	120	0	0
	CC	GO:0042611	MHC protein complex	19	0.006309	0.005403
		GO:0001772	Immunological synapse	32	0.002899	0.007356
	MF	GO:0042287	MHC protein binding	24	0	0.003098
		GO:0019865	Immunoglobulin binding	22	0	0.003835
COAD	BP	GO:0002269	Leukocyte activation involved in inflammatory response	31	0	0.007515
		GO:0032613	Interleukin-10 production	46	0	0.010735
		GO:0032633	Interleukin-4 production	34	0	0.011836
		GO:0042116	Macrophage activation	78	0	0.01362
		GO:0032612	Interleukin-1 production	86	0	0.01409
		GO:0071887	Leukocyte apoptotic process	103	0	0.014403
		GO:0032615	Interleukin-12 production	53	0	0.014703
		GO:0150076	Neuroinflammatory response	48	0	0.014859
		GO:0071706	Tumor necrosis factor superfamily cytokine production	133	0	0.014925
	CC	GO:0042611	MHC protein complex	19	0.008584	0.019271
	MF	GO:0019865	Immunoglobulin binding	22	0	0
		GO:0042287	MHC protein binding	24	0.006263	0.04006
LUAD	BP	GO:0045088	Regulation of innate immune response	125	0	0
		GO:0042110	T cell activation	149	0	0
		GO:0002694	Regulation of leukocyte activation	167	0	0
		GO:0070661	Leukocyte proliferation	98	0	0
		GO:0002250	Adaptive immune response	121	0	0.000551
		GO:0002697	Regulation of immune effector process	129	0	0.00058
		GO:0030101	Natural killer cell activation	24	0	0.000612
		GO:0032635	Interleukin-6 production	43	0	0.000648
		GO:0042116	Macrophage activation	28	0	0.000735
		GO:0002446	Neutrophil mediated immunity	147	0	0.000735
		GO:0002764	Immune response-regulating signaling pathway	159	0	0.000787
		GO:0002285	Lymphocyte activation involved in immune response	53	0	0.000826
		GO:0002449	Lymphocyte mediated immunity	85	0	0.000881
		GO:0002440	Production of molecular mediator of immune response	65	0	0.001502
		GO:0042113	B cell activation	66	0	0.002204
LUSC	BP	GO:0042116	Macrophage activation	78	0	0
		GO:0032635	Interleukin-6 production	120	0	0
		GO:0032612	Interleukin-1 production	86	0	0
		GO:0002446	Neutrophil mediated immunity	472	0	0
		GO:0050900	Leukocyte migration	394	0	0
		GO:0002250	Adaptive immune response	363	0	0
		GO:0032637	Interleukin-8 production	67	0	0
		GO:0002764	Immune response-regulating signaling pathway	452	0	0
	CC	GO:0042611	MHC protein complex	19	0	0.000887
		GO:0001772	Immunological synapse	32	0	0.001893
	MF	GO:0019865	Immunoglobulin binding	22	0	0
		GO:0042287	MHC protein binding	24	0.002283	0.005568
STAD	BP	GO:0002446	Neutrophil mediated immunity	473	0	0
		GO:0002764	Immune response-regulating signaling pathway	452	0	0
		GO:0032612	Interleukin-1 production	86	0	0
		GO:0002250	Adaptive immune response	368	0	0
		GO:0032623	Interleukin-2 production	63	0	0
		GO:0031349	Positive regulation of defense response	407	0	0
		GO:0032635	Interleukin-6 production	120	0	0
		GO:0006959	Humoral immune response	223	0	0
		GO:0002697	Regulation of immune effector process	365	0	0
		GO:0007159	Leukocyte cell–cell adhesion	310	0	0
		GO:0002694	Regulation of leukocyte activation	461	0	0
		GO:0002449	Lymphocyte mediated immunity	229	0	0
		GO:0002285	Lymphocyte activation involved in immune response	167	0	0
	CC	GO:0042611	MHC protein complex	19	0.009772	0.008677
		GO:0001772	Immunological synapse	32	0.003155	0.0107
	MF	GO:0019865	Immunoglobulin binding	22	0	0
		GO:0042287	MHC protein binding	24	0.006079	0.008962

Significant GO terms correlated with immunology were demonstrated in the table.

BRCA breast invasive carcinoma, COAD colon adenocarcinoma, LUAD lung Adenocarcinoma, LUSC lung squamous cell carcinoma, STAD stomach adenocarcinoma, GO gene ontology, BP biological process, CC cellular component, MF molecular function.