Table 2.

Enrichment pathway analysis results. The table shows results obtained by the FunRich tool. Only pathways related to angiogenesis are reported. For each time point, the percentage of enriched genes, the fold enrichment and the Bonferroni-adjusted p-value are reported. Not significant: fold enrichment p-value ≥ 0.05.

	3 h_vs._0 h			6 h_vs._0 h			6 h_vs._3 h
Pathway	% Enriched Genes	Fold Enrichment	p-Value (Bonferroni-Adjusted)	% Enriched Genes	Fold Enrichment	p-Value (Bonferroni-Adjusted)	% Enriched Genes	Fold Enrichment	p-Value (Bonferroni-Adjusted)
Beta1 integrin cell surface interactions	25.4	1.1854	0.0146	26.9	1.2561	1.0167 × 10−7	34.1	1.5901	1.441 × 10−7
EGFR-dependent Endothelin signalling events	24.2	1.1825	0.03440	25.9	1.2690	4.5939 × 10−8	33.6	1.645	1.3314 × 10−8
Endothelins	Not significant			26.1	1.26	1.3783 × 10−7	33.6	1.6222	4.1668 × 10−8
HIF-1-alpha transcription factor network	Not significant			Not significant			5.1	4.8831	8.0756 × 10−8
IGF1 pathway	24.2	1.1838	0.0297	25.9	1.2670	6.044 × 10−8	33.6	1.6424	1.5141 × 10−8
LKB1 signalling events	24.8	1.1964	0.0070	26.5	1.2809	4.0980 × 10−9	33.6	1.6210	4.4347 × 10−8
N-cadherin signalling events	Not significant			Not significant			8.2	2.0655	0.0252
Nectin adhesion pathway	24.2	1.1801	0.0409	26.0	1.2659	6.6551 × 10−8	34.1	1.6590	4.2976 × 10−9
PDGF receptor signalling network	24.3	1.1851	0.0257	26.06	1.2707	3.2165 × 10−8	33.8	1.6507	8.0949 × 10−9
Posttranslational regulation of adherens junction stability and disassembly	Not significant			Not significant			7.8	2.1230	0.0235
Proteoglycan syndecan-mediated signalling events	25.3	1.1846	0.0167	27.1	1.2724	7.3776 × 10−9	35.0	1.6389	5.2725 × 10−9
RAC1 signalling pathway	Not significant			Not significant			7.3	2.2556	0.0113
Regulation of CDC42 activity	Not significant			15.2	1.2478	0.0083	22.7	1.8607	1.1663 × 10−7
RhoA signalling pathway	Not significant			Not significant			7.3	2.2556	0.0113
Signalling events mediated by focal adhesion kinase	24.2	1.1834	0.0317	25.9	1.27	4.0022 × 10−8	33.6	1.6462	1.2483 × 10−8
Signalling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	24.3	1.1851	0.0257	26.0	1.2679	5.0634 × 10−8	33.6	1.6398	1.7211 × 10−8
Signalling events mediated by VEGFR1 and VEGFR2	24.7	1.1855	0.0240	26.1	1.2705	3.0898 × 10−8	33.8	1.6469	9.8334 × 10−9
Stabilization and expansion of the E-cadherin adherens junction	Not significant			Not significant			9.3	2.1399	0.0025
Syndecan-1-mediated signalling events	24.5	1.1881	0.0178	26.2	1.2721	2.1586 × 10−8	33.6	1.6310	2.6854 × 10−8
VEGF and VEGFR signalling network	24.4	1.1782	0.0455	26.2	1.2655	5.8984 × 10−8	33.8	1.6368	1.6437 × 10−8