Table 5.
Cox multivariate analysis of KRAS G12/G13 MAF as continuous and as dichotomous variable, regarding PFS and OS.
| PFS | OS | |||||
|---|---|---|---|---|---|---|
| Variable | HR a | 95% CI b | p-Value | HR a | 95% CI b | p-Value |
| Full multivariate Model | ||||||
| KRAS G12/G13 status | ||||||
| WT | 1.00 | |||||
| MUT | 3.12 | 1.72–5.67 | <0.001 | 2.53 | 1.40–4.56 | 0.002 |
| TNM stage | ||||||
| III | 1.00 | |||||
| IV | 1.60 | 0.82–3.13 | 0.170 | 1.97 | 0.94–4.15 | 0.073 |
| Metastatic organs | ||||||
| ≤2 | 1.00 | |||||
| >2 | 1.95 | 0.91–4.23 | 0.089 | 3.38 | 1.56–7.34 | 0.002 |
| Performance status | ||||||
| 0 | 1.00 | |||||
| 1 or 2 | 1.77 | 1.04–3.02 | 0.035 | 1.56 | 0.86–2.80 | 0.141 |
| KRAS G12/G13 MAF | ||||||
| Log10 (KRAS G12/G13 MAF) | 1.99 | 1.25–3.16 | 0.004 | 1.85 | 1.21–2.85 | 0.005 |
| TNM stage | ||||||
| III | 1.00 | |||||
| IV | 1.70 | 0.37–7.76 | 0.495 | 2.05 | 0.55–7.74 | 0.288 |
| Metastatic organs | ||||||
| ≤2 | 1.00 | |||||
| >2 | 1.32 | 0.48–3.63 | 0.590 | 2.88 | 1.07–7.80 | 0.037 |
| Performance status | ||||||
| 0 | 1.00 | |||||
| 1 or 2 | 2.29 | 0.99–5.30 | 0.030 | 1.88 | 0.80–4.43 | 0.148 |
| Reduced Multivariate Models | ||||||
| KRAS G12/G13 status c | ||||||
| MUT | 3.05 | 1.69–5.48 | <0.001 | 2.70 | 1.51–4.82 | 0.001 |
| KRAS G12/G13 MAF c | ||||||
| Log10 (KRAS G12/G13 MAF) | 1.82 | 1.16–2.86 | 0.009 | 1.93 | 1.23–3.03 | 0.004 |
| KRAS G12/G13 status d | ||||||
| MUT | 3.20 | 1.79–5.73 | <0.001 | 2.48 | 1.40–4.39 | 0.002 |
| KRAS G12/G13 MAF d | ||||||
| Log10 (KRAS G12/G13 MAF) | 1.92 | 1.22–3.04 | 0.005 | 1.95 | 1.23–3.08 | 0.004 |
| KRAS G12/G13 status e | ||||||
| MUT | 3.55 | 1.98–6.36 | <0.001 | 2.73 | 1.55–4.80 | 0.001 |
| KRAS G12/G13 MAF e | ||||||
| Log10 (KRAS G12/G13 MAF) | 2.08 | 1.32–3.28 | 0.002 | 1.89 | 1.21–2.95 | 0.005 |
a Hazard ratio, estimated from Cox proportional hazard regression model. b Confidence interval of the estimated HR. c Reduced multivariate model adjusted for TNM stage. d Reduced multivariate model adjusted for number of metastatic organs. e Reduced multivariate adjusted for patients’ performance status. The values in bold indicate statistical significance (p < 0.05).