Table 1.
Mutations in the Nrf-KeapI system responsible for cancer [69].
| Gene | Somatic Mutations | Cancer Types | References |
|---|---|---|---|
| KeapI | C23Y, D256G | Breast cancer | [70,71] |
| R234W, T330I, V660M, | Colorectal adenocarcinoma | [70,72] | |
| R470C | Cervical squamous carcinoma | [73] | |
| F107L, A159T, A188V, P412S, E611K | Epithelial ovarian cancer | [74] | |
| Q82H, S233N, F280L | Gastric adenocarcinoma | [70] | |
| S338L, G379D, | Gall bladder adenocarcinoma | [75] | |
| N183S, D236Y, L342M | Hepatocellular carcinoma | [70] | |
| C249Y, W554X | Liver cholangiocarcinoma | [75] | |
| E244K, G364C, R415G, G430C, W591L | Lung adenocarcinoma | [70,76] | |
| G333C | Lung non-small-cell carcinoma | [77] | |
| V42A, S45F, R320Q | Lung squamous cell carcinoma | [70,78] | |
| Y255H, T314M, D357N, | Prostrate adenocarcinoma | [70,75] | |
| Nrf2 | W24C, D29Y, R34Q, D77A, G81D | Cervical squamous carcinoma | [73,79] |
| D27Y, E78K, E79K, T80K, G81V, E82L | Esophagus squamous carcinoma | [79,80] | |
| D29G, Q75H, T80I | Head and neck cancer | [75] | |
| D29H, D77N, E79G | Larynx carcinoma | [80] | |
| E79Q, | Lung adenocarcinoma | [75] | |
| D77V, E79K, R34L, R34Q, R34Q | Lung non-small-cell carcinoma | [75,81] | |
| D77A, E79K, T80R, G81D, E82G | Lung squamous cell carcinoma | [75,76,80] | |
| L30F | Malignant melanoma | [79] | |
| G31A | Skin squamous cell carcinoma | [80] |