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NRF2 regulation in normal and stress conditions. (A). NRF2 activity in normal condition is maintained at low levels through KEAP1-dependent canonical ubiquitination and KEAP1-independent noncanonical pattern. (B). Stress stimuli, through electrophilic binding of KEAP1, induce its conformational modification and release of NRF2. NRF2 nuclear translocation transiently activates, through MAF binding, the transcription of a signature aimed to counteract the initial stress.
