Figure 2.

KEAP1-NRF2 modulation in cancers such as RCCs. The main pathways involved in KEAP1-NRF2 are epigenetic, transcriptional, and post-translational regulation in cancer. These pathways are generally mutated and deregulated in ccRCC or PRCC, thus they can account for the aberrant and persistent NRF2 activation observed in these tumor types. Dashed arrows indicate an indirect link between the two interactors of the pathway. Post-translational modifications are indicated as phosphorylation (P), ubiquitination (Ub), acetylation (Ac), and succination (2SC). Red dots on KEAP1 promoter indicate methylations.