Table 1.

Mutations and alterations of principal NRF2 target genes in PRCC and ccRCC.

Function	Genes	Mutations and Alterations
		PRCC	ccRCC
Antioxidant response	HMOX1	TM	MM
	GPX1	Del	MM
	TXN	MM	Del
Drug metabolism and disposition	NQO1	Amp	Amp
	AKR1B10	MM, Del	Amp
	AKR1C1	MM, Amp	MM
	AKR1C3	MM, Amp	-
Autophagy	SQSTM1	MM, Amp	Amp
Mitochondrial apoptosis	PARK7	Amp, Del	Del
Xenobiotic response and metabolism	AHR	MM	TM, Amp
NADPH generation and pentose synthesis	G6PD	Amp	MM, Amp
	IDH1	Del	MM, TM, Amp, Del

Mutations and alterations of NRF2 target genes were extracted through cBioPortal, analyzing samples in TCGA PanCancer Atlas. Alterations are indicated as missense mutations (MM), truncating mutations (TM), deletions (Del), amplifications (Amp), not mutated or altered (-).