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. 2020 Nov 20;25(22):5436. doi: 10.3390/molecules25225436

Figure 5.

Figure 5

Role of the AMP magainin in the African clawed frog in the defense against amphibian pathogens. The peptide is located in the dermis of the African clawed frog skin and conforms into an alpha helix upon interacting with a negatively charged membrane, resulting in the formation of toroidal pores in most instances. The peptide interferes with internal metabolic processes by activating the RecA gene, which causes DNA fragmentation [41]. This ultimately kills the pathogen. Image created with BioRender.com.