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Cytotoxicity of selected “simple” RhoB conjugates.
| Compound | A375 | HT29 | MCF-7 | A2780 | FaDu | NIH 3T3 |
|---|---|---|---|---|---|---|
| RhoB | >30 | >30 | >30 | >30 | >30 | >30 |
| 1 | 0.38 | 0.41 | 0.23 | 0.21 | 0.30 | 0.96 |
| 2 | 0.19 | 0.19 | 0.14 | 0.17 | 0.15 | 0.32 |
| 3 | >30 | >30 | >30 | >30 | >30 | >30 |
| 4 | 7.09 | 5.46 | 1.54 | 1.66 | 4.53 | >30 |
| 5 | 1.79 | 1.54 | 0.44 | 0.52 | 1.12 | 5.09 |
| 6 | 3.05 | 1.74 | 0.49 | 0.70 | 1.52 | 7.92 |
| 7 | 16.05 | 17.34 | 3.74 | 3.62 | 11.78 | >30 |
| 8 | 1.03 | 0.54 | 0.32 | 0.27 | 0.64 | 3.27 |
| 9 | >30 | >30 | 17.80 | 26.40 | >30 | >30 |
EC50 in μM from SRB assays; cut-off 30 μM.
