Skip to main content
. 2020 Nov 20;9(11):2510. doi: 10.3390/cells9112510

Figure 4.

Figure 4

Knockout of SIRT3 exacerbated Ang-II-induced iron overload. (A,B) Prussian blue staining showed that Ang-II infusion increased the iron content in the mouse kidneys, which was accentuated by SIRT3 knockout (n = 3/group). * p < 0.05, ** p < 0.01, *** p < 0.001. Data are means ± S.E.M. (C–E) SIRT3KO increased the expression of Ang-II-induced iron overload associated proteins acetyl-p53, heme oxygenase 1 (HO-1) and ferroportin (n = 3–4/group). * p < 0.05, ** p < 0.01, *** p < 0.001. Data are means ± S.E.M.