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Proposed scheme of a working model of the promotion of Ang-II-induced renal fibrosis by SIRT3KO. Sirtuin 3 deficiency sensitizes angiotensin-II-induced renal fibrosis by activating differentiation of pericytes into fibroblasts, by exacerbating iron overload and by accelerating endothelial dysfunction. HO-1, heme oxygenase 1; PFKFB3, 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3; GLUT1, glucose transporter 1; ROS, reactive oxygen species.
