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. 2020 Nov 20;25(22):5445. doi: 10.3390/molecules25225445

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AIMs inhibits Ki67 expression and intra-tumoral microvessel density (IMVD) in Hep3B cell-originated tumors in athymic nude mice. (A) Cell proliferation was demonstrated by Ki67 immunostaining. Reduction in Ki67 staining showed that AIM treatment reduces cell proliferation. (B) AIM assists in the decrease in angiogenesis which is shown by the CD34 staining. The decrease in the expression of CD34 shows the suppression of angiogenesis. The data are shown as the means ± SD of three independent experiments, * p < 0.05 between the treated and the untreated control group.