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. 2020 Nov 20;21(22):8793. doi: 10.3390/ijms21228793
ARDS acute respiratory distress syndrome
COVID-19 coronavirus disease 19
ALI acute lung injury
VILI ventilator-induced lung injury
LPS lipopolysaccharide
BLM bleomycin
EC endothelial cell
IEJ interendothelial junction
TJ tight junction
AJ adherens junction
GJ gap junction
JAM junctional adhesion molecule
VE-cadherin vascular endothelial cadherin
LMVEC lung microvascular endothelial cell
EG endothelial glycocalyx
ET-1 endothelin-1
NO nitric oxide
Ang-1 angiopoietin-1
RAAS renin–angiotensin–aldosterone system
ACE angiotensin converting enzyme
BALF bronchoalveolar lavage fluid
EMP endothelial microparticle
SARS severe acute respiratory syndrome
SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
rACE2 recombinant ACE2
PCEB pulmonary capillary endothelium-bound
eNOS endothelial nitric oxide synthase
iNOS inducible nitric oxide synthase
iEPO inhaled prostacyclin
IL interleukin
ICU intensive care unit
PMN polymorphonuclear cell
ROS reactive oxygen species
NET neutrophil extracellular trap
sE-selectin soluble E-selectin
sP-selectin soluble P-selectin
sICAM-1 soluble intercellular adhesion molecule-1
PECAM-1 platelet-endothelial cell adhesion molecule-1
vWF von Willebrand factor
TF tissue factor
PC protein C
APC activated protein C
TM thrombomodulin
EPCR endothelial protein C receptor
VAP ventilator-associated pneumonia
PAI-1 plasminogen activator inhibitor 1
PMEC pulmonary microvascular endothelial cell
rhTM recombinant human TM
rTM recombinant TM
VEGF vascular endothelial growth factor
VEGFR1 VEGF receptor 1
VEGFR2 VEGF receptor 2
FE fat embolism
AKI acute kidney injury
COVID-19 coronavirus disease-19
MicroCLOTS microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome