Table 2.
Gestational trimester of occurrence of Zika virus (ZIKV) infection, gender, the presence of coinfections in pregnancy, age at the application of BSID-III, the head circumference at birth and the current evaluation (z-score), the results of the BSID-III evaluation and the neurological examination of 26 non-microcephalic children exposed to the Zika virus in the intrauterine period, Manaus, Amazonas, Brazil.
| ID | Gen | Coinfection | Current Age (Months) | HC at Birth (Z-Score) | Current HC (Z-Score) | HC Classification | Cognition Score (IC 95%) | Language Score (IC 95%) | Motor Skills SCORE (IC 95%) | BSID-III Result | Neurological Examination | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1° GT ZIKV | 1 | F | No | - | −0.83 | −0.47 | Normo | 105 (97–113) | 106 (98–113) | 97 (90–105) | Normal | Adequate |
| 2 | F | No | 40 | 0.08 | 1.07 | Normo | 115 (106–122) | 124 (115–130) | 133 (123–138) | Normal | Adequate | |
| 3 | F | No | 41 | −1.28 | 0.6 | Normo | 100 (92–108) | 115 (107–121) | 103 (95–110) | Normal | Adequate | |
| 4 | F | No | 42 | −0.78 | −0.07 | Normo | 95 (87–103) | 91 (84–99) | 133 (123–138) | Normal | Adequate | |
| 5 | F | No | 41 | −0.02 | −1.03 | Normo | 85 (78–94) | 79 (73–88) | 64 (59–75) | Delayed | Altered | |
| 6 | M | Dengue | 33 | 1.24 | 0.81 | Normo | 100 (92–108) | 112 (104–118) | 103 (95–110) | Normal | Adequate | |
| 7 | M | Toxoplasm. | 40 | 0.08 | −1.14 | Normo | 85 (78–94) | 71 (66–80) | 85 (79–94) | Delayed | Altered | |
| Mean | - | - | - | 38.43 | −0.22 | −0.03 | - | 97.86 | 99.71 | 102.57 | - | - |
| 2° GT ZIKV | 8 | M | No | 25 | −0.78 | −0.08 | Normo | 105 (97–113) | 77 (71–86) | 91 (84–99) | Delayed | Adequate |
| 9 | F | No | 34 | 2 | −1.28 | Normo | 95 (87–103) | 89 (83–97) | 85 (79–94) | Normal | Altered | |
| 10 | M | No | 35 | −0.63 | −1.01 | Normo | 105 (97–113) | 112 (104–118) | 107 (99–114) | Normal | Adequate | |
| 11 | F | No | 36 | −1.62 | −1.67 | Normo | 100 (92–108) | 91 (84–99) | 82 (76–91) | Delayed | Adequate | |
| 12 | F | No | 37 | 1.11 | 1.18 | Normo | 100 (92–108) | 115 (107–121) | 107 (99–114) | Normal | Adequate | |
| 13 | M | No | 40 | 0.08 | −0.98 | Normo | 90 (83–99) | 77 (71–86) | 85 (79–94) | Delayed | Altered | |
| 14 | M | No | 40 | 2.16 | 1.94 | Macro resolved | 85 (78–94) | 71 (66–80) | 76 (70–86) | Delayed | Altered | |
| 15 | F | No | 41 | 0.22 | 0.69 | Normo | 105 (97–113) | 91 (84–99) | 97 (90–105) | Normal | Adequate | |
| 16 | F | No | 41 | 2.68 | 1.63 | Macro resolved | 115 (106–122) | 115 (107–121) | 103 (95–110) | Normal | Adequate | |
| 17 | M | HIV | 34 | 2.56 | 2.21 | Macro maintained | 90 (83–99) | 83 (77–91) | 73 (68–83) | Delayed | Altered | |
| 18 | M | Herpes | 38 | −2 | −0.16 | Normo | 80 (74–90) | 83 (77–91) | 85 (79–94) | Delayed | Adequate | |
| 19 | F | Dengue | 41 | 1.92 | 0.95 | Normo | 100 (92–108) | 106 (98–113) | 107 (99–114) | Adequate | Adequate | |
| Mean | - | - | - | 36.83 | 0.64 | 0.29 | - | 98 | 95.6 | 93 | - | - |
| 3° GT ZIKV | 20 | F | No | 36 | 1.94 | 1.11 | Normo | 105 (97–113) | 109 (101–116) | 103 (95–110) | Adequate | Adequate |
| 21 | M | No | 37 | 1.43 | 1.41 | Normo | 105 (97–113) | 124 (115–130) | 103 (95–110) | Adequate | Adequate | |
| 22 | M | No | 38 | −0.27 | 0.11 | Normo | 90 (83–99) | 118 (110–124) | 91 (84–99) | Adequate | Altered | |
| 23 | F | No | 38 | 1.94 | 0.41 | Normo | 105 (97–113) | 121 (112–127) | 100 (92–108) | Adequate | Adequate | |
| 24 | F | No | 41 | 1.38 | 0.41 | Normo | 80 (74–90) | 53 (49–64) | 82 (76–91) | Delayed | Altered | |
| 25 | M | No | 41 | −0.78 | −0.25 | Normo | 130 (119–135) | 89 (83–97) | 107 (99–114) | Adequate | Adequate | |
| 26 | M | No | 42 | −0.78 | 1.02 | Normo | 90 (83–99) | 115 (107–121) | 97 (90–105) | Adequate | Adequate | |
| Mean | - | - | - | 39.00 | 0.69 | 0.60 | - | 100.71 | 104.14 | 97.57 | - | - |
| Total Mean | - | - | - | 37.85 | 0.43 | 0.29 | - | 98.46 | 97.58 | 96.12 | - | - |
Id: identification; Gen: gender; HC: head circumference; GT: gestational trimester; ZIKV: Zika virus; CI 95%: confidence index of 95%.