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. Author manuscript; available in PMC: 2020 Nov 28.
Published in final edited form as: Nat Rev Mol Cell Biol. 2020 Sep 8;21(11):696–711. doi: 10.1038/s41580-020-00279-w

Fig. 1 |. Bone homeostasis.

Fig. 1 |

Bone homeostasis is achieved through the activity of osteoblast lineage cells and osteoclast lineage cells. Osteoblast lineage cells such as the osteoid (which is the unmineralized portion of bone matrix) secrete hydroxyapatite and calcium to promote bone mineralization and the formation of osteocytes. Osteoclast lineage cells resorb bone. The balance between the activity of the two cell lineages results in bone homeostasis. HSC, haematopoietic stem cell.