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. Author manuscript; available in PMC: 2020 Nov 28.
Published in final edited form as: Nat Rev Mol Cell Biol. 2020 Sep 8;21(11):696–711. doi: 10.1038/s41580-020-00279-w

Fig. 2 |. Skeletal stem cell hierarchy.

Fig. 2 |

Skeletal stem cells (SSCs) (and their progenitors) in mice and humans can be isolated on the basis of distinctive immunophenotypic cell surface markers. a | Human SSC hierarchy immunophenotypic profile, beginning with a human SSC at the apex, differentiating into a human bone, cartilage and stromal progenitor and into its committed progenitors: human cartilage progenitors, human osteoprogenitors and human stromal cells. b | Mouse SSC immunophenotypic profile, beginning with a mouse SSC at the apex, differentiating into a mouse bone, cartilage and stromal progenitor and into its committed progenitors: mouse cartilage progenitors, mouse osteoprogenitors, mouse B lymphocyte stromal progenitors, mouse 6C3 cells and mouse hepatic leukaemia factor-expressing cells.