Table 3.
Comparison of Physiological Parameters Between HFNC and COT Groups
| Characteristic | Group | Baseline | 24 h | 48 h | 72 h | 120 h | Before Discharge | pa |
|---|---|---|---|---|---|---|---|---|
| pH | HFNC | 7.38±0.04 | 7.36±0.06 | 7.40±0.04 | 7.41±0.05 | 7.40±0.04 | 7.40±0.04 | 0.864 |
| COT | 7.39±0.04 | 7.38±0.05 | 7.39±0.05 | 7.39±0.05 | 7.39±0.03 | 7.39±0.04 | 0.924 | |
| pc | 0.376 | 0.730 | 0.182 | 0.049 | 0.017 | 0.530 | 0.888b | |
| PaO2 (mmHg) | HFNC | 54.7±5.2 | 71.3±14.0 | 70.5±13.8 | 68.9±10.7 | 69.4±10.6 | 64.9±7.5 | 0.000 |
| COT | 54.9±4.9 | 73.8±9.2 | 73.1±10.4 | 70.9±5.6 | 71.1±6.0 | 64.3±5.4 | 0.000 | |
| pc | 0.680 | 0.119 | 0.143 | 0.151 | 0.237 | 0.578 | 0.219b | |
| PaCO2 (mmHg) | HFNC | 54.9±7.1 | 54.1±9.8 | 52.8±7.9 | 53.3±8.3 | 52.1±10.2 | 51.4±7.2 | 0.001 |
| COT | 54.2±6.0 | 56.9±10.1 | 54.1±8.6 | 54.1±8.7 | 54.4±10.2 | 49.1±9.7 | 0.034 | |
| pc | 0.325 | 0.030 | 0.320 | 0.496 | 0.173 | 0.108 | 0.306b | |
| SaO2 (%) | HFNC | 89.3±4.7 | 92.8±3.0 | 93.2±2.1 | 93.0±3.4 | 93.8±2.7 | 92.2±3.4 | 0.000 |
| COT | 89.0±4.6 | 93.5±2.7 | 93.7±2.2 | 93.6±2.7 | 94.1±2.5 | 92.8±3.5 | 0.000 | |
| pc | 0.649 | 0.079 | 0.111 | 0.185 | 0.395 | 0.227 | 0.325b | |
| Respiratory rate (bpm) | HFNC | 21.0±1.7 | 21.5±2.0 | 21.4±2.4 | 22.4±5.7 | 21.4±2.5 | 21.5±2.7 | 0.066 |
| COT | 21.1±1.9 | 23.1±7.6 | 22.4±5.7 | 21.8±2.2 | 21.8±2.3 | 21.4±1.9 | 0.024 | |
| pc | 0.790 | 0.024 | 0.067 | 0.294 | 0.253 | 0.628 | 0.150b |
Notes: Results are mean ± SD. Total number of patients present in each group at each time point. pa for overall comparisons of differences in each group over time. pb for overall comparisons of differences between groups over time. pc for comparisons of differences between groups at each time point.
Abbreviations: COT, conventional oxygen therapy; HFNC, high-flow nasal cannula oxygen therapy; PaO2, partial pressure of oxygen; PaCO2, partial pressure of carbon dioxide; SaO2, arterial oxygen saturation.