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. 2020 Nov 24;13:969–983. doi: 10.2147/JIR.S285985

Figure 3.

Figure 3

The severity of glomerular injury after cBSA immunization in CLU-KO mice. The severity of glomerular injury was determined in kidney sections by using semi-quantitative histological analyses. (A) Typical microscopic images of the renal cortex of mice in cBSA-WT and cBSA-KO groups. The tissue sections were PAS stained. A: artery, yellow star: glomerulus. Scale bar: 80 µm. (B) Glomerular atrophies (GA), the numbers of atrophic glomeruli in a high-powered field (hpf) of HE-stained sections. Each value presents the number of each mouse. *p = 0.2567 (cBSA-WT vs PBS-WT); **p < 0.0001 (cBSA-KO vs cBSA-WT). (C) Mesangial expansion (ME) was scored according to the PAS staining of thickening basement membrane or ECM deposit along the outer surface of the basement membrane. Each value presents the average score of 180 to 250 glomeruli of one animal. *p = 0.5974 (cBSA-WT vs PBS-WT); **p = 0.0026 (cBSA-KO vs cBSA-WT).