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. 2020 Nov 24;13:3107–3123. doi: 10.2147/JPR.S269549

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© 2020 Khalil et al.

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(A) Apparent clearance, (B) bodyweight-normalized apparent clearance, (C) apparent distribution volume, and (D) bodyweight-normalized apparent distribution volume versus age, using allometric scaling with estimated exponents (Table 3). Empirical Bayesian estimates (dots) are shown together with simulated relationship (median weight-for-age (solid line) as well as the 3rd and 97th weight-for-age percentile (dashed lines) of the CDC growth charts). Empirical Bayesian estimates of all results are scaled to age-specific oral bioavailability and stratified by gender. For bodyweight-normalized values, data were presented on logarithmic x-axis.

Abbreviation: CDC, Centers for Disease Control and Prevention.