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. 2020 Nov 24;13:3081–3094. doi: 10.2147/JPR.S275254

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© 2020 Liu et al.

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Upregulation of descending serotoninergic projection in CIPN rats. (A) The spinal 5-HT was significantly upregulated on days 7, 14 and 21 after paclitaxel injection compared with the naive and sham group. (B) The expression of Tph was significantly increased in the RVM on days 7, 14, and 21 in CIPN rats compared with the naive and sham group. * vs naive group, P < 0.05. ^# vs sham group, P < 0.05. n=3 per group.