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. 2020 Nov 24;12:12087–12098. doi: 10.2147/CMAR.S271165

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© 2020 Yuan et al.

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miR-515-5p enhanced drug sensitivity in vitro. (A) The drug resistance index of VCR, CBP, DDP, VP-16 and 5-Fu in SO-RB50/VCR and SO-RB50/CBP cells; (B) Expression of miR-515-5p in SO-RB50/VCR, SO-RB50/CBP and SO-RB50 cells was detected using RT-qPCR; (C) Expression of miR-515-5p in SO-RB50/VCR and SO-RB50/CBP cells after overexpression of miR-515-5p was detected using RT-qPCR; (D and E) SO-RB50 cell proliferation after overexpression of miR-515-5p was detected using CCK-8 assay and colony formation assay. Each experiment was repeated for three times independently. Data are presented as mean ± standard deviation. The t test was adopted for analysis of comparisons between two groups. One-way ANOVA was employed for the comparisons among multiple groups and Tukey’s multiple comparison test was applied for the post hoc test, *p < 0.05, **p < 0.01, ***p < 0.001.

Abbreviations: VCR, vincristine; CBP, carboplatin; DDP, cisplatin; VP-16, etoposide; 5-Fu, 5-fluorouracil; NC, negative control; RT-qPCR, reverse transcription quantitative polymerase chain reaction; ANOVA, analysis of variance.