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. 2020 Nov 23;8(11):1840. doi: 10.3390/microorganisms8111840

Figure 1.

Figure 1

Neighbor-net phylogenetic grouping of representative animal and human coronaviruses (CoVs). Blue, yellow, green, and rose circles indicate the genus Alphacoronavirus (subgenera Duvinacovirus, Pedacovirus, Rhinacovirus, Setracovirus, and Tegacovirus), Betacoronavirus (subgenera Embecovirus, Hibecovirus, Merbecovirus, Nobecovirus, and Sarbecovirus), Gammacoronavirus, and Deltacoronavirus, respectively. Full-length sequences (n = 78) of the spike protein encoding genes of human and animal CoVs were retrieved from the NCBI GenBank portal (https://www.ncbi.nlm. nih.gov/genbank/) and subjected to multiple alignment using the ClustalW program embedded in MEGA 7.0 software. The resultant alignment file was used to generate a neighbor-net phylogenetic tree with the SplitsTree 4.0 program (http://www.splitstree.org/).