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. 2020 Nov 20;9(11):3741. doi: 10.3390/jcm9113741

Figure 2.

Figure 2

Genes in the epidermal differentiation complex located on chromosome 1q21.3. Most genes encoding barrier-related proteins are located in the epidermal differentiation complex on chromosome 1q21.3. The epidermal differentiation complex includes cornified envelope precursor gene family members such as LOR and IVL, S100A protein gene family members such as S100A7, and fused gene family members such as FLG and FLG2. The fused gene family was generated by fusion of the cornified envelope precursor gene and the S100A protein gene.