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. 2020 Nov 23;10(11):1590. doi: 10.3390/biom10111590

Figure 1.

Figure 1

(A) Sirt1 activity levels by groups in the study population. Subjects with heart failure with preserved ejection fraction showed significant lower Sirt1 activity values than both subjects with heart failure with mid-range EF (HFmrEF) and those with heart failure with reduced EF (HFrEF) (p < 0.0001), without any difference compared to the no heart failure (HF) controls (Ctr). (B) Circulating ACE2 activity by groups in the study population. The HFpEF subjects showed significant lower ACE2 activity values than both HFmrEF and HFrEF (p < 0.0001), without any difference compared to the no HF controls (Ctr). (C) Circulating TNF-alpha levels by groups in the study population. An increasing trend of plasma TNF-alpha levels from the HFpEF through the HFmrEF to the HFrEF patients without reaching statistical significance was found.