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. 2020 Nov 23;10(11):895. doi: 10.3390/brainsci10110895

Table 1.

U-47700 series opioid receptor binding affinities (data from Loew et al. [35]).

a Compound MOR
KD
(nm)		 KOR
KD
(nm)		 Ratio MOR/KOR
U-47700
(3,4-dichloro-N-[(1R,2R)-2-
(dimethylamino)cyclohexyl]-
N-methylbenzamide)		 5.3 910 0.006
U-47109
(3,4-dichloro-N-[(1R,2R)-2-
(dimethylamino)cyclohexyl]
benzamide)		 59 910 0.065
U-48520
(4-chloro-N-[(1R,2R)-2-
-(dimethylamino)cyclohexyl]-
N-methylbenzamide)		 200 2900 0.069
U-77891
3,4-dibromo-N-methyl-N-((5S,6R)-
1-methyl-1-azaspiro[4.5]decan-6-yl)
benzamide		 2 2300 0.001

a Loew et al. [35] did not specify stereochemistry of compounds tested; here we employ IUPAC naming of the compounds.