Skip to main content
. 2020 Nov 21;21(22):8824. doi: 10.3390/ijms21228824

Figure 2.

Figure 2

Domain structure and positions of 14-3-3 binding motifs of kinases regulated in the 14-3-3-dependent manner. Kinase domains are shown in blue, the 14-3-3 binding sites are shown as red dots. BRS, B-RAF specific domain; RBD, Ras binding domain; CRD, cysteine rich domain; TBD, TRX-binding domain; TPR, tetratricopeptide repeats domain; PH, pleckstrin homology domain; CC, coiled-coil region; RR, N-terminal regulatory site; AIS/CaM, autoinhibitory segment/CaM-binding domain; Helical, helical domain; ARD, armadillo repeat; ANK, ankyrin repeat; LRR, leucine-rich repeat; ROC, Ras of the complex GTPase domain; COR, C-terminal of ROC; WD40, WD40 or beta-transducin repeat. The kinases differ in their length and they are not shown on the same scale.