Table 1.
GREAT associations made with 2X differential pS187-H1.4 signal-associated genes. Top ten categories in decreasing order of p-value listed. Genomic Regions Enrichment of Annotations Tool (GREAT) Association MSigDB Perturbation *.
| Term Name | Binom Raw p-Value |
|---|---|
| Genes bound by ESR1 and up-regulated by estradiol in MCF-7 cells (breast cancer) expressing constitutevly active form of AKT1 | 7.64 × 10−126 |
| Genes bound by ESR1 and up-regulated by estradiol in MCF-7 cells (breast cancer). | 3.2717 × 10−107 |
| The ‘ER-alpha profile’: genes up-regulated in T47D cells upon activation of ESR1 by estradiol (E2) | 1.9154 × 10−92 |
| Genes upregulated in MCF7 cells (breast cancer) at 6 h of estradiol treatment. | 3.2198 × 10−65 |
| Genes upregulated in MCF7 cells (breast cancer) at 24 h of estradiol treatment. | 1.0162 × 10−59 |
| Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB. | 4.9913 × 10−59 |
| Genes up-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. | 2.038 × 10−50 |
| Genes whose expression negatively correlated with resistance of breast cancer cell lines to dasatinib. | 2.7928 × 10−48 |
| Genes regulated by ESR1 in MCF7 cells (breast cancer) | 3.5364 × 10−45 |
| Genes down-regulated in breast cancer tumor (formed by MCF7 xenografts) resistant to tamoxifen. | 5.1164 × 10−44 |
* MSigDB Perturbation ontology contains datasets that represent gene expression signatures of genetic and chemical perturbations.