Table 1.

Overview of selected successful drug reprofiling candidates.

Drug Name	Original Indication	New Indication	Year of Approval
Zidovudine	Cancer	AIDS	1987 [8]
Minoxidil	Hypertension	Hair loss	1988 [9]
Sildenafil	Angina	Erectile dysfunction	1998 [10]
Thalidomide	Morning sickness	Erythema nodosum leprosum and multiple myeloma	1998 [11] and 2006 [12]
Celecoxib	Pain and inflammation	Familial adenomatous polyps	2000 [13]
Atomoxetine	Parkinson disease	ADHD	2002 [14]
Duloxetine	Depression	SUI	2004 [15]
Rituximab	Various cancers	Rheumatoid arthritis	2006 [16]
Raloxifene	Osteoporosis	Breast cancer	2007 [17]
Fingolimod	Transplant rejection	MS	2010 [18]
Dapoxetine	Analgesia and depression	Premature ejaculation	2012 [19]
Topiramate	Epilepsy	Obesity	2012 [20]
Ketoconazole	Fungal infections	Cushing syndrome	2014 [21]
Aspirin	Analgesia	Colorectal cancer	2015 [22]

AIDS = Acquired Immunodeficiency Syndrome. ADHD = Attention deficit hyperactivity disorder. SUI = Stress urinary incontinence. MS = Multiple Sclerosis.