Table 1.
Axes of suppressor lncRNAs and their role in ovarian cancer progression.
| Axis lncRNA/miRNA/mRNA | LncRNA Expression; Involvement in Suppression of Progression, Influence on Prognosis, Survival, Drug Sensitivity | References |
|---|---|---|
| ADAMTS9-AS2/miR-182-5p/FOXF2 | downregulated; reduced invasion, EMT in vitro, in vivo | [72] |
| EPB41L4A-AS2/miR-103a/RUNX1T1 | inhibited migration, invasion in vitro, in vivo | [73] |
| GAS5/miR-21/SPRY2 | suppressed migration, invasion in vitro, better prognosis | [74] |
| GAS5/miR-196a-5p/HOXA5 | downregulated; suppressed proliferation, EMT, migration | [75] |
| HAND2-AS1/miR-340-5p/BCL2L11 | downregulated, hypermethylated; inhibits migration, invasion, adhesion to extracellular matrix in vitro, in vivo | [68,76] |
| HOTAIRM1/miR-106a-5p/ARHGAP24 | downregulated; inhibited migration, invasion, metastasis | [77] |
| LINC01088/miR-24-1-5p/PAK4 | under-expressed; inhibited proliferation, xenografts | [78] |
| LINC01125/miR-1972 | reduced proliferation, enhanced cisplatin sensitivity | [79] |
| LINC01133/miR-205/LRRK2 | suppresses invasion, migration in vitro, in vivo | [80] |
| MAGI2-AS3/miR-15-5p (miR-374a-5p, miR-374b-5p)/PTEN | downregulated, hypermethylated; decreased migration, viability, adhesion to extra cellular matrix | [81] |
| MAGI2-AS3/miR-525-5p/MXD1 | inhibited cell cycle, migration, invasion; MYC signaling | [69] |
| MIR503HG/miR-31-5p | downregulated; inhibited invasion, migration; methylation of miR-31 gene by MIR503HG | [82] |
| MORT/miR-21 | downregulated; inhibited proliferation, in vitro | [83] |
| WDFY3-AS2/miR-18a/RORA | suppressed migration, invasion, EMT, in vitro, in vivo | [84] |
| XIST/miR-214-3p/PTEN | downregulated; inhibited migration, invasion, in vitro, in vivo, xenografts, increase chemo-sensitivity | [85,86] |
| Suppressor lncRNA with dual functions | ||
| MEG3/miR-421/PDGFRA | upregulated; promoted angiogenesis, invasion | [87] |
| MEG3/miR-205-5p/PTEN | downregulated; inhibited migration, invasion, increase cisplatin sensitivity | [88,89] |
Note: lncRNA, long non-coding RNA; EMT, epithelial-mesenchymal transition; ADAMTS9-AS2, ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) antisense RNA 2; FOXF2, forkhead-related transcription factor 2; EPB41L4A-AS2, erythrocyte membrane protein band 4.1 like 4A (EPB41L4A) antisense RNA 2; RUNX1T1, runt-related transcription factor 1 (RUNX1) partner transcriptional co-repressor 1; GAS5, growth arrest-specific 5; SPRY2, sprouty homolog 2; HOXA5, homeobox A5; HAND2-AS1, heart and neural crest derivatives expressed 2 (HAND2) antisense RNA 1; BCL2L11, BCL2 like 11 (apoptosis facilitator); HOTAIRM1, HOXA transcript antisense RNA, myeloid-specific 1; ARHGAP24, Rho GTPase activating protein 24; PAK4, p21-activated kinase 4; LRRK2, leucine rich repeat kinase 2; MAGI2-AS3, membrane-associated guanylate kinase, WW and PDZ domain-containing 2 (MAGI2) antisense RNA 3; PTEN, phosphatase and tensin homolog; MXD1, MYC-associated factor X (MAX) dimerization protein 1; MORT, mortal obligate RNA transcript; WDFY3-AS2, WD repeat and FYVE domain-containing 3 (WDFY3) antisense RNA 2; RORA, RAR-related orphan receptor A; XIST, X inactive specific transcript; MEG3, maternally expressed 3; PDGFRA, platelet-derived growth factor receptor alpha; One of the official synonymous names of the lncRNA/mRNA from GeneCards [90] is provided, which gives the best idea of its function.