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Schematic illustration of engineered FokI–dCas9 (fdCas9) constructs. Constructs are generated by (A) Tsai et al., (B) Guilinger et al., (C) Nakagawa et al., (D) Aouida et al., and (E) Havlicek et al. fdCas9 expression is driven by a strong constitutive human promoter (CMV and CAG). FokI endonuclease is fused to the N-terminal of the dead Cas9 (dCas9) [22,23,24,25,26].
