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. 2020 Nov 23;9(11):2522. doi: 10.3390/cells9112522

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Representative images of transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Parental cells (BCPAP^P and TPC1^P) presented loss of apical-basal polarity and concentration of mitochondria in one pole of the cells. The presence of small and circular mitochondria suggests mitochondrial fission. Vacuoles and mitochondrial fission are showed (arrow). Remarkably, the apical-basal polarity and mitochondria morphology are somewhat restored in LIMD2-edited cells (BCPAP^E and TPC1^E); (B) Schematic model of parental (expressing LIMD2) and edited cells (complete KO of LIMD2).