Table 5.

Comparative pharmacokinetic parameters of optimized formulation and marketed tablets (mean ± SD, n = 6).

PK Parameters	Optimized SLC-SNTs	Marketed SLC-Tablets
Cmax (ng/mL)	360 ± 20	205 ± 11
Tmax (min)	30 ± 0.0	90 ± 6.0
t1/2 (h)	4.46 ± 1.46	6.2 ± 1.1
AUC 0-t (ng/mL h)	1801 ± 400	1248.25 ± 233.125
AUC0-inf (ng/mL h)	1846.36 ± 727.34	1281.5 ± 316.82
AUMC 0-inf (ng/mL h2)	11,801.119 ±10,058.3	7185.7 ± 1398.60
Kel (h−1)	0.154 ± 0.02	0.110 ± 0.040
MRT (h)	6.39 ± 2.10	7.16 ± 1.3
Relative BA (%)	144.28%	-